Precision Oncology

Tumor Molecular Profiling

TMB Assessment

class MolecularProfiler:
    def compute_tmb(self, mutations, sequenced_bases_mb):
        return len(mutations) / sequenced_bases_mb

    def predict_immunotherapy_response(self, features):
        score = (0.3 * min(features.get('tmb', 0) / 20, 1.0) +
                 0.25 * features.get('pdl1_tps', 0) / 100 +
                 0.2 * features.get('immune_infiltration', 0) +
                 0.15 * (1 if features.get('msi') == 'MSI-High' else 0))
        return min(score, 1.0)

Immunotherapy Response Prediction

Neoantigen Prediction

Biomarker Integration

Targeted Therapy Selection